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KMID : 0351819930340020117
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Kyunpook University Medical Journal
1993 Volume.34 No. 2 p.117 ~ p.126
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Effect of Angiotensin converting Enzyme Inhibitors on the Endothelium-Dependent Relaxation in the Isolated Aorta from Spontaneously Hypertensive Rats and Normotensive Wistar-Kyoto Rats
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Abstract
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Using the isolated aortic rings of the spontaneoulsly hypertensive rats(SHR) and normotensive Wistar-Kyoto rats(WKY), we evaluated the effect of angiotensin converting enzyme inhibitros, captopril and enalapril, on the endothelium-dependent
relaxation.
Acetylcholine, histamine, and nitroprusside produced relaxation of isolated aortic ring from SHR and WKY. ACEI treatment enhanced histamine-induced relaxation in SHR but not in WKY. Acetylcholine-induced relaxation was inhibited by the presence
of
NG-monomethyl-L-arginine(LNMMA) and high concentration of extracellular potassium and histamine-induced relaxation was inhibited by the presence of LNMMA only. In the studies with SHR the enhancing effect of ACEI on histamine-induced relaxation
was
shown in the presence of the high concentration of extracellular potassium but not in LNMMA and the effect of ACEI on acetylcholine-induced relaxation was shown in the presence of LNMMA and high concentration of extracellular potassium. In the
studies
with WKY the enhancing effect of ACEI on acetylcholine-induced relaxation was not prominent but statistically significant in the presence of the high concentration of extracellular potassium and in LNMMA but not significant in the case of
histamine-induced relaxation. Relaxation by nitroprusside was not altered by ACEI treatment in both SHR and WKY.
These results demontstrated that ACEI altered both EDHF-and EDRF-dependent response promineantly in SHR and slightly in WKY, And we suggest that the augmentation of endothelium-dependent relaxation by ACEI may be largely due to the recovery of
endothelial function
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KEYWORD
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